2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite
2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly (ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia[1][2].
Product Specifications
CAS Number
2245842-16-2
UNSPSC
12352005
Hazard Statement
H315, H317, H319, H335, H360
Target
Nucleoside Antimetabolite/Analog; Xanthine Oxidase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/2-fluoro-5-o-dmt-2-deoxyinosine-3-ce-phosphoramidite.html
Purity
98.81
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC(C=C1)=CC=C1C(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)OC[C@@H]4[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](F)[C@H](N5C(NC=NC6=O)=C6N=C5)O4
Molecular Formula
C40H46FN6O7P
Molecular Weight
772.80
Precautions
H315, H317, H319, H335, H360
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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