2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite

2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly (ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia[1][2].

Product Specifications

CAS Number

[2245842-16-2]

UNSPSC

12352005

Hazard Statement

H315, H317, H319, H335, H360

Target

Nucleoside Antimetabolite/Analog; Xanthine Oxidase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/2-fluoro-5-o-dmt-2-deoxyinosine-3-ce-phosphoramidite.html

Purity

98.81

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC(C=C1)=CC=C1C(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)OC[C@@H]4[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](F)[C@H](N5C(NC=NC6=O)=C6N=C5)O4

Molecular Formula

C40H46FN6O7P

Molecular Weight

772.80

Precautions

H315, H317, H319, H335, H360

References & Citations

[1]Virág L, Szabó C. Purines inhibit poly (ADP-ribose) polymerase activation and modulate oxidant-induced cell death. FASEB J. 2001 Jan;15 (1) :99-107.|[2]Saugstad OD. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res. 1988 Feb;23 (2) :143-50.