Azelaic acid

Azelaic acid is a nine-carbon dicarboxylic acid. Azelaic acid has antimicrobial activity against Propionibacterium acnes and Staphylococcus epidermidis through inhibition of microbial cellular prorein synthesis. Azelaic acid has hypopigmentation action resulting from its ability to scavenge free radicals[1][2].

Product Specifications

CAS Number

[123-99-9]

Product Name Alternative

Nonanedioic acid

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Endogenous Metabolite

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Azelaic-acid.html

Purity

98.0

Solubility

DMSO : ≥ 100 mg/mL

Smiles

OC(CCCCCCCC(O)=O)=O

Molecular Formula

C9H16O4

Molecular Weight

188.22

Precautions

H302, H315, H319, H335

References & Citations

[1]Jung HW, et al. Priming in systemic plant immunity. Science. 2009 Apr 3;324 (5923) :89-91.|[2]Liu RH, et al. Azelaic acid in the treatment of papulopustular rosacea: a systematic review of randomized controlled trials. Arch Dermatol. 2006 Aug;142 (8) :1047-52.|[3]J P Leeming, et al. The in vitro antimicrobial effect of azelaic acid. Br J Dermatol. 1986 Nov;115 (5) :551-6.|[4]Harald Gollnick, et al. Azelaic acid 15% gel in the treatment of rosacea. |[5]Dongdong Zhang, et al. Azelaic Acid Exerts Antileukemia Effects against Acute Myeloid Leukemia by Regulating the Prdxs/ROS Signaling Pathway. Oxid Med Cell Longev. 2020 Dec 23:2020:1295984.|[6]L Lemic-Stojcevic, et al. Dongdong Zhang, et al. Effect of azelaic acid on melanoma cells in culture. Exp Dermatol. 1995 Apr;4 (2) :79-81.