Destruxin A

Destruxin A is a cyclic hexadepsipeptide metabolite from the fungus Metarhizium anisopliae. Destruxins show insecticidal, anti-viral, and phytotoxic properties. Destruxin A suppresses the Drosophila humoral immune response in Drosophila melanogaster. It increases peptidoglycan recognition protein (PGRP), prophenoloxidase (proPO) system and affects diverse pathways, including apoptosis, calcium signaling, and development in the larvae of Plutella xylostella.