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Stafia-1

Stafia-1 is a potent STAT5a inhibitor (K i=10.9 μM, IC50=22.2 μM) . Stafia-1 displays high selectivity over STAT5b and other STAT family members[1].

Product Specifications

CAS Number

2582757-90-0

UNSPSC

12352005

Target

STAT

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/stafia-1.html

Purity

99.39

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

OP(OC1=CC(C2=CC(OC)=C(OC)C(OC)=C2)=CC(C3=CC(OC)=C(OC)C(OC)=C3)=C1)(O)=O

Molecular Formula

C24H27O10P

Molecular Weight

506.44

References & Citations

[1]Natarajan K, et al. Stafia-1: a STAT5a-Selective Inhibitor Developed via Docking-Based Screening of in Silico O-Phosphorylated Fragments. Chemistry. 2020;26 (1) :148-154.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

STAT5

Available Sizes

Frequently Asked Questions

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