Stafia-1
Stafia-1 is a potent STAT5a inhibitor (K i=10.9 μM, IC50=22.2 μM) . Stafia-1 displays high selectivity over STAT5b and other STAT family members[1].
Product Specifications
CAS Number
[2582757-90-0]
UNSPSC
12352005
Target
STAT
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/stafia-1.html
Purity
99.39
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
OP(OC1=CC(C2=CC(OC)=C(OC)C(OC)=C2)=CC(C3=CC(OC)=C(OC)C(OC)=C3)=C1)(O)=O
Molecular Formula
C24H27O10P
Molecular Weight
506.44
References & Citations
[1]Natarajan K, et al. Stafia-1: a STAT5a-Selective Inhibitor Developed via Docking-Based Screening of in Silico O-Phosphorylated Fragments. Chemistry. 2020;26 (1) :148-154.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT5
Available Sizes
Curated Selection
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