Crk p38 Recombinant Rabbit Monoclonal Antibody [JE38-60]
Selected Variant
HA722453
Size: 100 µL
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
Adapter molecule crk Proto-oncogene c-Crk p38 CRK
Swiss Prot
P46108 Human, Q63768 Rat
Cellular Locus
Cell membrane. Cytoplasm.
Host
Rabbit
Species Reactivity
Human, Rat
Immunogen
Recombinant protein within Human Crk p38 aa 1-100 / 304.
Isotype
IgG
Clone
JE38-60
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB
Positive Control
HeLa cell lysate, HepG2 cell lysate, C6 cell lysate, PC-12 cell lysate.
Concentration
1 mg/mL
Dilution
WB: 1:1,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 34 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
Price
Frequently Asked Questions
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