Ac-VLPE-FMK

Ac-VLPE-FMK, a tetrapeptidyl mono-fluoromethyl ketone (m-FMK), is a Cat-B and Cat-L inhibitor. Ac-VLPE-FMK can be used for the research of cancer aggressiveness[1][2].

Product Specifications

CAS Number

[2679825-27-3]

Product Name Alternative

Ac-Val-Leu-Pro-Glu (OMe) -CH2F

UNSPSC

12352005

Target

Cathepsin

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ac-vlpe-fmk.html

Purity

99.0

Solubility

10 mM in DMSO

Smiles

O=C(N(CCC1)[C@@H]1C(N[C@H](C(CF)=O)CCC(OC)=O)=O)[C@H](CC(C)C)NC([C@H](C(C)C)NC(C)=O)=O

Molecular Formula

C25H41FN4O7

Molecular Weight

528.61

References & Citations

[1]Rudzińska M, et, al. Cysteine Cathepsins Inhibition Affects Their Expression and Human Renal Cancer Cell Phenotype. Cancers (Basel) . 2020 May 21;12 (5) :1310.|[2]Citarella A, et, al. Peptidyl Fluoromethyl Ketones and Their Applications in Medicinal Chemistry. Molecules. 2020 Sep 3;25 (17) :4031.