UU-T01
UU-T01 is a selective inhibitor for β-Catenin/T-cell factor 4 protein-protein interaction (β-catenin/Tcf PPI) with an Ki value of 3.14 µM. UU-T01 is directly combined with β-catenin, and the KD value is 0.531 µM[1].
Product Specifications
CAS Number
1417162-83-4
UNSPSC
12352005
Target
β-catenin
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/uu-t01.html
Purity
96.92
Solubility
10 mM in DMSO
Smiles
ON1N=CC2=C1C=CC(CCC3=NNN=N3)=C2
Molecular Formula
C10H10N6O
Molecular Weight
230.23
References & Citations
[1]Guo W, et al. Hot spot-based design of small-molecule inhibitors for protein-protein interactions. Bioorg Med Chem Lett. 2014 Jun 1;24 (11) :2546-54. |[2]Cui C, et al. Is β-catenin a druggable target for cancer therapy?[J]. Trends in biochemical sciences, 2018, 43 (8) : 623-634.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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