Nebivolol

Nebivolol (R 065824) is an orally active beta receptor blocker and has the high beta (1) -receptor affinity. Nebivolol has direct vasodilator properties and adrenergic blocking characteristics. Nebivolol can be used for the research of kinds of diseases such as hypertension, coronary artery disease, congestive heart failure and ischemic heart disease[1][2].

Product Specifications

CAS Number

[118457-14-0]

Product Name Alternative

R 065824

UNSPSC

12352005

Hazard Statement

H302

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cardiovascular Disease; Endocrinology; Cancer

Assay Protocol

https://www.medchemexpress.com/nebivolol.html

Purity

99.82

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

FC1=CC=C2C(CC[C@]([C@@H](O)CNC[C@H](O)[C@@]3([H])CCC(C=C(F)C=C4)=C4O3)([H])O2)=C1

Molecular Formula

C22H25F2NO4

Molecular Weight

405.44

Precautions

H302

References & Citations

[1]Brehm BR, et al. Effects of nebivolol on proliferation and apoptosis of human coronary artery smooth muscle and endothelial cells. Cardiovasc Res. 2001 Feb 1;49 (2) :430-9.|[2]Thomas Münzel, et al. Nebivolol: the somewhat-different beta-adrenergic receptor blocker. J Am Coll Cardiol. 2009 Oct 13;54 (16) :1491-9.