Fortunellin
Product Specifications
UNSPSC Description
Fortunellin, is a flavonoid, that can be isolated from the fruits of Fortunella margarita (kumquat). Fortunellin exhibits little toxicity to mice and suppresses inflammation and ROS generation in H9C2 cells induced by LPS. Fortunellin protects against fructose-induced inflammation and oxidative stress by enhancing AMPK/Nrf2 pathway. Fortunellin can be used for diabetic cardiomyopathy research[1].
Target Antigen
AMPK; Keap1-Nrf2
Type
Natural Products
Related Pathways
Epigenetics;NF-κB;PI3K/Akt/mTOR
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/fortunellin.html
Purity
96.51
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C=C(OC2=CC(O[C@H]3[C@H](O[C@H]4[C@H](O)[C@H](O)[C@@H](O)[C@@H](O4)C)[C@@H](O)[C@H](O)[C@H](O3)CO)=CC(O)=C12)C5=CC=C(C=C5)OC
Molecular Weight
592.55
References & Citations
[1]Zhao C, et al. Fortunellin protects against high fructose-induced diabetic heart injury in mice by suppressing inflammation and oxidative stress via AMPK/Nrf-2 pathway regulation. Biochem Biophys Res Commun. 2017 Aug 19;490(2):552-559.|[2]Entezari M, et al. AMPK signaling in diabetes mellitus, insulin resistance and diabetic complications: A pre-clinical and clinical investigation. Biomed Pharmacother. 2022 Feb;146:112563.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-119678/Fortunellin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-119678/Fortunellin-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
20633-93-6
Available Sizes
Curated Selection
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