Fortunellin

Fortunellin, is a flavonoid, that can be isolated from the fruits of Fortunella margarita (kumquat) . Fortunellin exhibits little toxicity to mice and suppresses inflammation and ROS generation in H9C2 cells induced by LPS. Fortunellin protects against fructose-induced inflammation and oxidative stress by enhancing AMPK/Nrf2 pathway. Fortunellin can be used for diabetic cardiomyopathy research[1].

Product Specifications

CAS Number

[20633-93-6]

UNSPSC

12352005

Target

AMPK; Keap1-Nrf2

Type

Natural Products

Related Pathways

Epigenetics; NF-κB; PI3K/Akt/mTOR

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/fortunellin.html

Purity

98.31

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C=C(OC2=CC(O[C@H]3[C@H](O[C@H]4[C@H](O)[C@H](O)[C@@H](O)[C@@H](O4)C)[C@@H](O)[C@H](O)[C@H](O3)CO)=CC(O)=C12)C5=CC=C(C=C5)OC

Molecular Formula

C28H32O14

Molecular Weight

592.55

References & Citations

[1]Zhao C, et al. Fortunellin protects against high fructose-induced diabetic heart injury in mice by suppressing inflammation and oxidative stress via AMPK/Nrf-2 pathway regulation. Biochem Biophys Res Commun. 2017 Aug 19;490 (2) :552-559.|[2]Entezari M, et al. AMPK signaling in diabetes mellitus, insulin resistance and diabetic complications: A pre-clinical and clinical investigation. Biomed Pharmacother. 2022 Feb;146:112563.