Sclerodione
Sclerodione is a metabolite that can be produced by the Scleroderris canker fungus, Gremmeniellaabietina. Sclerodione has antifungal activity. Sclerodione is a lipase inhibitor (IC50: 1 μM) [1][2][3].
Product Specifications
CAS Number
104855-19-8
UNSPSC
12352005
Target
Fungal; Lipase
Type
Natural Products
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/sclerodione.html
Solubility
10 mM in DMSO
Smiles
CC(C1=C2C(C3=O)=C(C4=C1O[C@H](C4(C)C)C)O)=CC(O)=C2C3=O
Molecular Formula
C18H16O5
Molecular Weight
312.32
References & Citations
[1]William A. et al. Metabolites produced by the Scleroderris canker fungus, Gremmeniellaabietina. Part 1. Canadian Journal of Chemistry. 1986. 64 (8) : 1585-1589.|[2]Hidayat Hussain, et al. Phytochemical investigation and antimicrobial activity of an endophytic fungus Phoma sp.Journal of King Saud University - Science. Volume 27, Issue 1, January 2015, Pages 92-95. |[3]Macabeo APG, et al. Alpha-Glucosidase- and Lipase-Inhibitory Phenalenones from a New Species of Pseudolophiostoma Originating from Thailand. Molecules. 2020 Feb 20;25 (4) :965.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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