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Idebenone (Standard)

Idebenone (Standard) is the analytical standard of Idebenone. This product is intended for research and analytical applications. Idebenone, a well-appreciated mitochondrial protectant, exhibits protective efficacy against neurotoxicity and can be used for the research of Alzheimer's disease, Huntington's disease. Idebenone (oxidised form) has a dose-dependent inhibitory effect on the enzymatic metabolism of arachidonic acid in astroglial homogenates (IC50=16.65 μM) [1]. Idebenone, a coenzyme Q10 analog and an antioxidant, induces apoptotic cell death in the human dopaminergic neuroblastoma SHSY-5Y cells[2]. Idebenone quickly crosses the blood-brain barrier.

Product Specifications

CAS Number

58186-27-9

UNSPSC

12352005

Target

Apoptosis; Mitochondrial Metabolism; Reference Standards

Type

Reference Standards

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; Others

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/idebenone-standard.html

Purity

96.98

Smiles

O=C1C(CCCCCCCCCCO)=C(C)C(C(OC)=C1OC)=O

Molecular Formula

C19H30O5

Molecular Weight

338.44

References & Citations

[1]G Civenni, et al. Inhibitory effect of the neuroprotective agent idebenone on arachidonic acid metabolism in astrocytes.Eur J Pharmacol. 1999 Apr 9;370 (2) :161-7.|[2]Kwok-Keung Tai, et al. Idebenone induces apoptotic cell death in the human dopaminergic neuroblastoma SHSY-5Y cells. Neurotox Res. 2011 Nov;20 (4) :321-8.

Shipping Conditions

Room Temperature

Storage Conditions

4°C, sealed storage, away from light and moisture

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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