5-Methyl-2′-O-methyl-uridine

5-Methyl-2’-O-methyl-uridine (2'-O-methyl-5-methyluridine) is a thymidine analog. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis. 5-Methyl-2’-O-methyl-uridine is a modified nucleoside that can be found in tRNA isolated from rabbit liver[1][2].

Product Specifications

CAS Number

[55486-09-4]

Product Name Alternative

2'-O-Methyl-5-methyluridine

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/5-methyl-2-o-methyl-uridine.html

Concentration

10mM

Purity

97.44

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

OC[C@@H]1[C@@H](O)[C@@H](OC)[C@H](N2C(NC(C(C)=C2)=O)=O)O1

Molecular Formula

C11H16N2O6

Molecular Weight

272.26

Precautions

H315, H319, H335

References & Citations

[1]Cavanagh BL, et al. Thymidine analogues for tracking DNA synthesis. Molecules. 2011 Sep 15;16 (9) :7980-93.|[2]Gross, H. J., et al., (1974) . 2'-O-methyl ribothymidine: a component of rabbit liver lysine transfer RNA. Nucleic acids research, 1 (1), 35–43