Fumaric acid (Standard)

Fumaric acid (Standard) is the analytical standard of Fumaric acid. This product is intended for research and analytical applications. Fumaric acid is an unsaturated dicarbonic acid, an intermediate product of the citric acid cycle that provides intracellular energy in the form of ATP. Fumaric acid exerts anti-inflammatory effects by inhibiting the NF-κB signaling pathway dependent on p38 MAPK. Fumaric acid can be used in the study of pregnancy-induced hypertension[1][2][3].

Product Specifications

CAS Number

[110-17-8]

UNSPSC

12352211

Hazard Statement

H319

Target

Endogenous Metabolite; NF-κB; p38 MAPK; Reference Standards

Type

Reference Standards

Related Pathways

MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/fumaric-acid-standard.html

Purity

99.93

Smiles

O=C(O)/C=C/C(O)=O

Molecular Formula

C4H4O4

Molecular Weight

116.07

Precautions

P264-P280-P305+P351+P338

References & Citations

[1]Whelan DT, et al. Fumaric aciduria: a new organic aciduria, associated with mental retardation and speech impairment. Clin Chim Acta. 1983 Aug 31;132 (3) :301-8.|[2]Roh KB, et al. Fumaric acid attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-κB signaling. Food Chem Toxicol. 2013 Aug;58:423-31.|[3]Zhou Y, et al. Fumaric acid and succinic acid treat gestational hypertension by downregulating the expression of KCNMB1 and TET1. Exp Ther Med. 2021 Oct;22 (4) :1072.