ZLC491
ZLC491 is an orally active CDK12/13 PROTAC degrader. ZLC491 can be used in anticancer research[1].
Product Specifications
CAS Number
[3053716-46-1]
UNSPSC
12352005
Target
CDK; PROTACs
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/zlc491.html
Purity
98.51
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N([C@@H]1CC[C@H](CC1)NC2=CC=C(C=N2)C#N)C3=CC=C(C=C3)N4CCN(CC4)C5CCN(CC5)C6=CC7=C(C=C6F)C(N(C7=O)C8CCC(NC8=O)=O)=O)NCC9=CC=CC=C9
Molecular Formula
C48H51FN10O5
Molecular Weight
866.98
References & Citations
[1]Zhou L, et al. Discovery of ZLC491 as a Potent, Selective, and Orally Bioavailable CDK12/13 PROTAC Degrader. J Med Chem. 2024 Oct 24;67 (20) :18247-18264.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK12; CDK13
Available Sizes
Curated Selection
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