Clitorin

Clitorin is an orally active flavonoid compound that can be isolated from Carica papaya. Clitorin is an inhibitor of EGFR (IC50: 89.58 nM) and aromatase (IC50: 77.41 nM) . Clitorin has antioxidant and anti-tumor activities. In the DPPH and ABTS radical scavenging assays, Clitorin has IC50 values of 91.96 ppm and 250.45 ppm, respectively. In addition, Clitorin can regulate lipogenesis and fatty acid oxidation and can be used in the research of non-alcoholic fatty liver disease[1][2][3].

Product Specifications

CAS Number

[55804-74-5]

UNSPSC

12352005

Target

Acetyl-CoA Carboxylase; AMPK; Cytochrome P450; EGFR; Fatty Acid Synthase (FASN) ; HMG-CoA Reductase (HMGCR) ; PPAR

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; JAK/STAT Signaling; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/clitorin.html

Purity

99.45

Smiles

O=C1C(O[C@H]2[C@@H]([C@H]([C@H](O)[C@@H](CO[C@H]3[C@@H]([C@@H]([C@@H](O)[C@H](C)O3)O)O)O2)O)O[C@@]4([H])[C@@H]([C@@H]([C@@H](O)[C@H](C)O4)O)O)=C(C5=CC=C(O)C=C5)OC6=CC(O)=CC(O)=C61

Molecular Formula

C33H40O19

Molecular Weight

740.66

References & Citations

[1]Cominguez DC, et al. Clitorin ameliorates western diet-induced hepatic steatosis by regulating lipogenesis and fatty acid oxidation in vivo and in vitro. Sci Rep. 2022 Mar 9;12 (1) :4154.|[2]Teh B P, et al. Clitorin and manghaslin from Carica papaya leaf juice: characterisation and antioxidant properties. 2023.|[3]Hamed ANE, et al. Chemical constituents from Carica papaya Linn. leaves as potential cytotoxic, EGFRwt and aromatase (CYP19A) inhibitors; a study supported by molecular docking. RSC Adv. 2022 Mar 23;12 (15) :9154-9162.