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Meclofenamic acid (sodium)

Meclofenamic acid (Meclofenamate) sodium is a non-steroidal anti-inflammatory agent (NSAID) . Meclofenamic acid sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat - and obesity-related enzyme (FTO) . Meclofenamic acid sodium has anti-inflammatory and antitumor activities[1][2][3].

Product Specifications

CAS Number

6385-02-0

Product Name Alternative

Meclofenamate (sodium)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; Fat Mass and Obesity-associated Protein (FTO) ; Gap Junction Protein

Type

Reference compound

Related Pathways

Cytoskeleton; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/meclofenamate-sodium.html

Purity

99.89

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(O[Na])C1=CC=CC=C1NC2=C(Cl)C=CC(C)=C2Cl

Molecular Formula

C14H10Cl2NNaO2

Molecular Weight

318.13

Precautions

H302, H315, H319, H335

References & Citations

[1]Schober W, et al. Meclofenamic acid for inhibition of human vascular smooth muscle cell proliferation and migration: an in vitro study. Cardiovasc Intervent Radiol. 2002 Jan-Feb;25 (1) :57-63.|[2]Chen H, et al. Meclofenamic Acid Restores Gefinitib Sensitivity by Downregulating Breast Cancer Resistance Protein and Multidrug Resistance Protein 7 via FTO/m6A-Demethylation/c-Myc in Non-Small Cell Lung Cancer. Front Oncol. 2022 Apr 21;12:870636.|[3]Schrier DJ, et al. The topical anti-inflammatory effects of a topical preparation of meclofenamic acid on carrageenan-induced footpad swelling in mice. J Pharm Pharmacol. 1987 Jan;39 (1) :57-9.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

Biomater Adv. 2023 Nov:154:213634.|Cancer Commun (Lond) . 2025 May;45 (5) :608-631.|PLoS Pathog. 2025 Jan 21;21 (1) :e1012895.|Sensor Actuat B-Chem. 2021, 129983.|Theranostics. 2021 Jul 25;11 (17) :8464-8479.|Biomed Opt Express. 2021 Mar 9;12 (4) :1962-1973.|SSRN. 2025 Jan 27.

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