ODN 2216 (sodium)
ODN 2216 sodium is a human-specific TLR9 (toll-like receptor 9) ligand or agonist. ODN 2216 sodium induces high amounts of IFN-α and IFN-β. ODN 2216 sodium induces IFN-α by pDC (plasmacytoid DC) and IL-12 (p40) production by DC (dendritic cells) . ODN 2216 sodium stimulates IFN-γ production in peripheral blood mononuclear cells (PBMC), which is indirect and mediated by IFN-α/β. ODN 2216 sodium can activate NK cells and promote IFN-γ production of TCR-triggered CD4+ T cells[1][2][3][4][5].
Product Specifications
UNSPSC
12352208
Target
Toll-like Receptor (TLR)
Type
Oligonucleotides
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/odn-2216-sodium.html
Purity
98.57
Solubility
10 mM in H2O
Smiles
[ODN2216(sodium)]
Molecular Weight
6432 (free acid)
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Available Sizes
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TAF1B (TATA Box-binding Protein-associated Factor RNA Polymerase I Subunit B, RNA Polymerase I-specific TBP-associated Factor 63kD, TAFI63, TATA Box-binding Protein-associated Factor 1B, TBP-associated Factor 1B, Transcription Initiation Factor SL1/TIF-IB