BVFP

BVFP binds to the PGRN588–593 peptide with a Kd of 20 μM. BVFP can disrupt PGRN-SORT1 binding. BVFP also inhibits SORT1-mediated rPGRN endocytosis[1].

Product Specifications

CAS Number

357158-20-4

UNSPSC

12352005

Target

Neurotensin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bvfp.html

Concentration

10mM

Purity

98.12

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1N=C(C=C(C(F)(F)F)N1)/C=C/C2=CC(Br)=CC=C2

Molecular Formula

C13H8BrF3N2O

Molecular Weight

345.11

References & Citations

[1]Lee WC, et al. Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency. Hum Mol Genet. 2014 Mar 15;23 (6) :1467-78.