Manumycin A
Manumycin A is a polyketide antibiotic and an inhibitor of thioredoxin reductase 1 (TrxR-1) . Manumycin A can inhibit the growth of breast cancer cells and exert its anti-tumor activity through LC3. Manumycin A can downregulate the release of pro-inflammatory cytokines in human monocytes stimulated by TNF α, and has potential anti-inflammatory activity. Manumycin A can inhibit the Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration resistant prostate cancer cells to suppress exosome biogenesis and secretion[1][3][4].
Product Specifications
CAS Number
52665-74-4
UNSPSC
12352005
Hazard Statement
H302+H312, H319
Target
Antibiotic; Apoptosis; Atg8/LC3; Farnesyl Transferase; Phospholipase; Ras; TNF Receptor
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Autophagy; GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/manumycin-a.html
Purity
99.27
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CCCC[C@@H](C)/C=C(C)/C=C(C)/C(NC1=C[C@](/C=C/C=C/C=C/C(NC2=C(O)CCC2=O)=O)(O)[C@]3([H])O[C@]3([H])C1=O)=O
Molecular Formula
C31H38N2O7
Molecular Weight
550.64
Precautions
H302+H312, H319
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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