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ADP-β-S (trilithium)

ADP-β-S trilithium is the trilithium salt form of ADP-β-S (HY-134353) . ADP-β-S trilithium is the activator for P2Y12 receptor, which upregulates levels of IL-1βand IL-6 production in microglial cells, promotes the phosphorylation and nuclear translocation of NF-κB, and enhances the activation of the NLRP3 inflammasome[1].

Product Specifications

CAS Number

[73536-95-5]

Product Name Alternative

Adenosine 5'- (β-thiodiphosphate) (trilithium)

UNSPSC

12352005

Hazard Statement

H302, H371

Target

NF-κB; P2Y Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/adp-β-s-trilithium.html

Purity

94.9

Solubility

H2O : 20 mg/mL (ultrasonic; warming)

Smiles

O[C@H]1[C@@H](O)[C@H](N2C=NC3=C(N=CN=C32)N)O[C@@H]1COP(OP(O[Li])(S[Li])=O)(O[Li])=O

Molecular Formula

C10H12Li3N5O9P2S

Molecular Weight

461.07

Precautions

H302, H371

References & Citations

[1]Suzuki T, et al., Extracellular ADP augments microglial inflammasome and NF-κB activation via the P2Y12 receptor. Eur J Immunol. 2020 Feb;50 (2) :205-219.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

P2Y12 Receptor

Available Sizes

Curated Selection

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