AF/LE Purified Anti-Mouse IL-17A Antibody[17F3]

The 17F3 monoclonal antibody reacts with mouse IL-17A a 15-20 kDa cytokine expressed by Th17 cells, γδ T cells, iNKT cells, NK cells, LTi cells, neutrophils, and intestinal Paneth cells. IL-17A has pleiotropic effects in immunoregulation and inflammation. It plays an important role in anti-microbial and chronic inflammation by inducing cytokine and chemokine production, neutrophil influx, and the production of antibacterial peptides but it is also an inflammatory mediator in the development of autoimmune diseases including rheumatoid arthritis, asthma, multiple sclerosis, and psoriasis. The 17F3 antibody has been shown to neutralize IL-18A in vivo.

IL-17CTLA; Cytotoxic T-lymphocyte-associated antigen; IL-17Acytotoxic T-lymphocyte-associated protein; CTLA8cytotoxic T-lymphocyte-associated serine esterase; CTLA 8; CTLA8cytotoxic T-lymphocyte-associated serine esterase 8; Ctla9; IL-17A; IL-17Acytotoxic T-lymphocyte-associated protein 8; IL-17CTLA-8; Interleukin-17A; IL-17; CTLA-8; Il17a; Cytotoxic T-lymphocyte-associated antigen 8; Ctla8; Il17; CTLA8; CTLA-8; CTLA8cytotoxic T-lymphocyte-associated serine esterase 8; Cytotoxic T-lymphocyte-associated antigen 8; IL17; IL-17; IL17A; IL-17A; IL-17Acytotoxic T-lymphocyte-associated protein 8; IL-17CTLA-8

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.