AdipoRon

AdipoRon is an orally active adiponectin receptor (AdipoR) agonist, binding to AdipoR1 and AdipoR2 with Kds of 1.8 and 3.1 μM, respectively.

Product Specifications

CAS Number

[924416-43-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Adiponectin Receptor

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/AdipoRon.html

Purity

99.88

Solubility

DMSO : 62.5 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

O=C(NC1CCN(CC2=CC=CC=C2)CC1)COC3=CC=C(C(C4=CC=CC=C4)=O)C=C3

Molecular Formula

C27H28N2O3

Molecular Weight

428.53

Precautions

H302, H315, H319, H335

References & Citations

[1]Okada-Iwabu M, et al. A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature. 2013 Nov 28;503 (7477) :493-9.|[2]Wang Y, et al. Hepatoprotective effects of AdipoRon against d-galactosamine-induced liver injury in mice. Eur J Pharm Sci. 2016 Aug 9;93:123-131.|[3]Zhang Y, et al. AdipoRon, the first orally active adiponectin receptor activator, attenuates postischemic myocardial apoptosis through both AMPK-mediated and AMPK-independent signalings. Am J Physiol Endocrinol Metab. 2015 Aug 1;309 (3) :E275-82.|[4]Hong K, et al. Adiponectin Receptor Agonist, AdipoRon, Causes Vasorelaxation Predominantly Via a Direct Smooth Muscle Action. Microcirculation. 2016 Apr;23 (3) :207-20.