AKB-6899

AKB-6899, a prolyl hydroxylase domain 3 (PHD3) inhibitor, is a selective HIF-2α stabilizer. AKB-6899 also increases soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages, and has antitumor and antiangiogenic effects[1].

Product Specifications

CAS Number

[1007377-55-0]

Product Name Alternative

KPT-8602 (Z-isomer),CL29926; (±)-Imazamox,MKC242 (free base),MKC250

UNSPSC

12352005

Target

HIF/HIF Prolyl-Hydroxylase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/akb-6899.html

Concentration

10mM

Purity

99.95

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(CNC(C1=NC=C(C=C1O)C2=CC=CC(F)=C2)=O)O

Molecular Formula

C14H11FN2O4

Molecular Weight

290.25

References & Citations

[1]Julie M Roda, et al. Stabilization of HIF-2α induces sVEGFR-1 production from tumor-associated macrophages and decreases tumor growth in a murine melanoma model. J Immunol. 2012 Sep 15;189 (6) :3168-77.