Cabozantinib-d6
Cabozantinib-d6 is the deuterium labeled Cabozantinib. Cabozantinib is a potent multiple receptor tyrosine kinases (RTKs) inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively[1][2][3].
Product Specifications
CAS Number
1802168-46-2
Product Name Alternative
XL184-d6; BMS-907351-d6
UNSPSC
12352005
Target
Apoptosis; c-Kit; c-Met/HGFR; FLT3; TAM Receptor; VEGFR
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
98.14
Solubility
DMSO : 25mg/mL (ultrasonic) |H2O : 1mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C(NC1=CC=C(OC=2C3=C(C=C(OC([2H])([2H])[2H])C(OC([2H])([2H])[2H])=C3)N=CC2)C=C1)(=O)C4(C(NC5=CC=C(F)C=C5)=O)CC4
Molecular Formula
C28H18D6FN3O5
Molecular Weight
507.54
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
Axl
Available Sizes
Frequently Asked Questions
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