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(2R,4R) -Fmoc-D-Pro (4-N3) -OH

(2R,4R) -Fmoc-D-Pro (4-N3) -OH (cis-4-Azido-N-Fmoc-D-proline) is a click chemistry reagent containing an azide group[1]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Product Specifications

CAS Number

1378847-51-8

Product Name Alternative

Cis-4-Azido-N-Fmoc-D-proline

UNSPSC

12352005

Hazard Statement

H315-H319-H335-H372

Target

ADC Linker

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/2r-4r-fmoc-d-pro-4-n3-oh.html

Solubility

10 mM in DMSO

Smiles

O=C(N1[C@H](C[C@H](C1)N=[N+]=[N-])C(O)=O)OCC2C3=CC=CC=C3C4=CC=CC=C42

Molecular Formula

C20H18N4O4

Molecular Weight

378.38

Precautions

P260-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501

References & Citations

[1]Rashad AA, et al. Macrocyclic Envelope Glycoprotein Antagonists that Irreversibly Inactivate HIV-1 before Host Cell Encounter. J Med Chem. 2015 Sep 24;58 (18) :7603-8.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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