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PAR-4 Agonist Peptide, amide

PAR-4 Agonist Peptide, amide (PAR-4-AP; AY-NH2) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist.

Product Specifications

CAS Number

352017-71-1

Product Name Alternative

PAR-4-AP; AY-NH2

UNSPSC

12352209

Target

Protease Activated Receptor (PAR)

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/PAR-4_Agonist_Peptide,_amide.html

Purity

99.87

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

OC(C=C1)=CC=C1C[C@H](NC([C@@H](N)C)=O)C(N2[C@@H](CCC2)C(NCC(N[C@@H](CCCCN)C(N[C@H](C(N)=O)CC3=CC=CC=C3)=O)=O)=O)=O

Molecular Formula

C34H48N8O7

Molecular Weight

680.79

References & Citations

[1]Annaházi A, et al. Proteinase-activated receptor-4 evoked colorectal analgesia in mice: an endogenously activatedfeed-back loop in visceral inflammatory pain. Neurogastroenterol Motil. 2012 Jan;24 (1) :76-85, e13.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

Scientific Category

Peptides

Clinical Information

No Development Reported

Citation 01

Immunity. 2022 Feb 8;55 (2) :224-236.e5.|Mol Nutr Food Res. 2022 Jul;66 (13) :e2200166.

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