Doramapimod
Doramapimod (BIRB 796) is an orally active, highly potent p38 MAPK inhibitor, which has an IC50 for p38α=38 nM, for p38β=65 nM, for p38γ=200 nM, and for p38δ=520 nM. Doramapimod has picomolar affinity for p38 kinase (Kd=0.1 nM) . Doramapimod also inhibits B-Raf with an IC50 of 83 nM[1][2].
Product Specifications
CAS Number
[285983-48-4]
Product Name Alternative
BIRB 796
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; p38 MAPK; Raf
Type
Reference compound
Related Pathways
Autophagy; MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/Doramapimod.html
Purity
99.98
Solubility
DMSO : 100 mg/mL (ultrasonic) |Ethanol : 33.33 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC(C(C)(C)C)=NN1C2=CC=C(C)C=C2)NC3=C4C=CC=CC4=C(OCCN5CCOCC5)C=C3
Molecular Formula
C31H37N5O3
Molecular Weight
527.66
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-10320/Doramapimod-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-10320/Doramapimod-SDS-MedChemExpress.pdf
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
B-Raf; p38 MAPK; p38α; p38β; p38γ; p38δ
Available Sizes
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