AMG-458

AMG-458 is a potent, selective and orally bioavailable c-Met inhibitor, with Ki values of 1.2 nM and 2.0 nM for human and mouse c-Met, respectively[1].

Product Specifications

CAS Number

[913376-83-7]

UNSPSC

12352005

Target

C-Met/HGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/amg-458.html

Concentration

10mM

Purity

98.41

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=C(C)N(CC(C)(O)C)N(C2=CC=CC=C2)C1=O)NC3=NC=C(OC4=CC=NC5=CC(OC)=CC=C45)C=C3

Molecular Formula

C30H29N5O5

Molecular Weight

539.58

References & Citations

[1]Longbin Liu, et al. Discovery of a potent, selective, and orally bioavailable c-Met inhibitor: 1- (2-hydroxy-2-methylpropyl) -N- (5- (7-methoxyquinolin-4-yloxy) pyridin-2-yl) -5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (AMG 458) . J Med Chem. 2008 Jul 10;51 (13) :3688-91.