Anethole

Anethole is a type of orally active aromatic compound that is widely found in nature and used as a flavoring agent. Anethole possesses anticancer, anti-inflammatory, antioxidant, antibacterial, antifungal, anesthetic, estrogenic, central nervous system depressant, hypnotic, insecticidal, and gastroprotective effects. Anethole can be used in the study of oxidative stress-related skin diseases and prostate cancer[1][2][3][4][5].

Product Specifications

CAS Number

[104-46-1]

Product Name Alternative

Anise camphor; p-Propenylanisole; Isoestragole

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Bacterial; Fungal; MMP; NF-κB

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Anethole.html

Purity

99.81

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C/C=C/C1=CC=C(OC)C=C1

Molecular Formula

C10H12O

Molecular Weight

148.21

Precautions

H302, H315, H319, H335

References & Citations

[1]Freire R S, et al. Synthesis and antioxidant, anti-inflammatory and gastroprotector activities of anethole and related compounds[J]. Bioorganic & medicinal chemistry, 2005, 13 (13) : 4353-4358. |[2] Galicka A, Krętowski R, Nazaruk J, et al. Anethole prevents hydrogen peroxide-induced apoptosis and collagen metabolism alterations in human skin fibroblasts[J]. Molecular and Cellular Biochemistry, 2014, 394: 217-224. |[3]Fujita K, et al. Anethole, a potential antimicrobial synergist, converts a fungistatic dodecanol to a fungicidal agent[J]. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 2007, 21 (1) : 47-51.|[4]Kang P, et al. Anti-inflammatory effects of anethole in lipopolysaccharide-induced acute lung injury in mice[J]. Life sciences, 2013, 93 (24) : 955-961. |[5]Al-Harbi M M, et al. Influence of anethole treatment on the tumour induced by Ehrlich ascites carcinoma cells in paw of Swiss albino mice[J]. European Journal of Cancer Prevention, 1995, 4 (4) : 307-318.