RXR antagonist 1
Product Specifications
UNSPSC Description
RXR antagonist 1 (compound 6a) is a retinoid X receptor (RXR) modulator. RXR antagonist 1 shows potent RXR-antagonistic activity, with a pA2 of 8.06. RXR antagonist 1 can be used for type 2 diabetes research[1].
Target Antigen
RAR/RXR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rxr-antagonist-1.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCCCCOC1=CC2=C(C(C)(CCC2(C)C)C)C=C1N3C(C(F)(F)F)=NC4=C3C=CC(C(O)=O)=C4
Molecular Weight
502.57
References & Citations
[1]Masaki Watanabe, et al. Increased Molecular Flexibility Widens the Gap between Ki and Kd values in Screening for Retinoid X Receptor Modulators. ACS Med. Chem. Lett. 2022, 13, 2, 211-217.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-144377/RXR-antagonist-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-144377/RXR-antagonist-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
3010910-40-1
Available Sizes
Curated Selection
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