RXR antagonist 1

RXR antagonist 1 (compound 6a) is a retinoid X receptor (RXR) modulator. RXR antagonist 1 shows potent RXR-antagonistic activity, with a pA2 of 8.06. RXR antagonist 1 can be used for type 2 diabetes research[1].

Product Specifications

CAS Number

[3010910-40-1]

UNSPSC

12352005

Target

RAR/RXR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/rxr-antagonist-1.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCCCCOC1=CC2=C(C(C)(CCC2(C)C)C)C=C1N3C(C(F)(F)F)=NC4=C3C=CC(C(O)=O)=C4

Molecular Formula

C28H33F3N2O3

Molecular Weight

502.57

References & Citations

[1]Masaki Watanabe, et al. Increased Molecular Flexibility Widens the Gap between Ki and Kd values in Screening for Retinoid X Receptor Modulators. ACS Med. Chem. Lett. 2022, 13, 2, 211-217.