RXR antagonist 1
RXR antagonist 1 (compound 6a) is a retinoid X receptor (RXR) modulator. RXR antagonist 1 shows potent RXR-antagonistic activity, with a pA2 of 8.06. RXR antagonist 1 can be used for type 2 diabetes research[1].
Product Specifications
CAS Number
[3010910-40-1]
UNSPSC
12352005
Target
RAR/RXR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rxr-antagonist-1.html
Purity
99.94
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCCCCOC1=CC2=C(C(C)(CCC2(C)C)C)C=C1N3C(C(F)(F)F)=NC4=C3C=CC(C(O)=O)=C4
Molecular Formula
C28H33F3N2O3
Molecular Weight
502.57
References & Citations
[1]Masaki Watanabe, et al. Increased Molecular Flexibility Widens the Gap between Ki and Kd values in Screening for Retinoid X Receptor Modulators. ACS Med. Chem. Lett. 2022, 13, 2, 211-217.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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