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1-Piperazinehexanoic acid-thalidomide

1-Piperazinehexanoic acid-thalidomide is a conjugate of E3 ligase ligand and linker that serve as a key intermediate for the synthesis of complete JMV7048 (HY-162704) [1].

Product Specifications

CAS Number

[2819682-33-0]

UNSPSC

12352005

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/1-piperazinehexanoic-acid-thalidomide.html

Purity

98.30

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)CCCCCN1CCN(C2=CC=C(C(N(C3CCC(NC3=O)=O)C4=O)=O)C4=C2)CC1

Molecular Formula

C23H28N4O6

Molecular Weight

456.49

References & Citations

[1]Lucile Bansard, A potent agonist-based PROTAC targeting Pregnane X Receptor that delays colon cancer relapse. bioRxiv 2024.06.18.599474

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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