1-Piperazinehexanoic acid-thalidomide
1-Piperazinehexanoic acid-thalidomide is a conjugate of E3 ligase ligand and linker that serve as a key intermediate for the synthesis of complete JMV7048 (HY-162704) [1].
Product Specifications
CAS Number
[2819682-33-0]
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/1-piperazinehexanoic-acid-thalidomide.html
Purity
98.30
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)CCCCCN1CCN(C2=CC=C(C(N(C3CCC(NC3=O)=O)C4=O)=O)C4=C2)CC1
Molecular Formula
C23H28N4O6
Molecular Weight
456.49
References & Citations
[1]Lucile Bansard, A potent agonist-based PROTAC targeting Pregnane X Receptor that delays colon cancer relapse. bioRxiv 2024.06.18.599474
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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