Bisindolylmaleimide IV

Bisindolylmaleimide IV (Arcyriarubin A) is a potent protein kinase C (PKC) inhibitor, with IC50s ranging from 0.1 to 0.55 μM. Bisindolylmaleimide IV also inhibits PKA (IC50=3.1-11.8μM) [1]. Bisindolylmaleimide IV is a potent, selective inhibitor of human cytomegalovirus (HCMV) replication in cell culture with an IC50 of 0.2 μM[2].

Product Specifications

CAS Number

[119139-23-0]

Product Name Alternative

Arcyriarubin A

UNSPSC

12352005

Hazard Statement

H301-H311-H331-H341

Target

CMV; PKC

Type

Reference compound

Related Pathways

Anti-infection; Epigenetics; TGF-beta/Smad

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/bisindolylmaleimide-iv.html

Purity

99.71

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(C(C1=CNC2=C1C=CC=C2)=C3C4=CNC5=C4C=CC=C5)NC3=O

Molecular Formula

C20H13N3O2

Molecular Weight

327.34

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P403+P233-P405-P501

References & Citations

[1]Slater MJ, et al. Indolocarbazoles: potent, selective inhibitors of human cytomegalovirus replication. Bioorg Med Chem. 1999 Jun;7 (6) :1067-74.|[2]Davis PD, et al. Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides. J Med Chem. 1992 Jan;35 (1) :177-84.