Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Rifamycin (sodium)

Rifamycin sodium (Rifamycin SV monosodium) is an orally active ansamycin antibiotic. Rifamycin sodium inhibits DNA-dependent RNA synthesis. Rifamycin sodium has antibacterial activity against Mycobacterium tuberculosis. Rifamycin sodium interferes with hepatic bile acid metabolism. Rifamycin sodium has anti-inflammatory effects. Rifamycin sodium can be used in the study of Mycobacterium tuberculosis, Bacteroides fragilis infection, and Lipopolysaccharide -induced inflammation[1][2][3][4][5][6][7][8][9][10][11].

Product Specifications

CAS Number

14897-39-3

Product Name Alternative

Rifamycin SV (sodium)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Bacterial; DNA/RNA Synthesis

Type

Natural Products

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/rifamycin-sodium.html

Purity

99.56

Solubility

DMSO : 175 mg/mL (ultrasonic)

Smiles

O=C1C2=C(C([O-])=CC(NC(/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@H]3C)=O)=C4O)C4=C(O)C(C)=C2O[C@@]1(O/C=C/[C@@H]([C@H]([C@@]3([H])OC(C)=O)C)OC)C.[Na+]

Molecular Formula

C37H46NNaO12

Molecular Weight

719.75

Precautions

H302, H315, H319, H335

References & Citations

[1]Floss HG, et al. Rifamycin-mode of action, resistance, and biosynthesis. Chem Rev. 2005 Feb;105 (2) :621-32.|[2]Fattinger K, et al. Rifamycin SV and rifampicin exhibit differential inhibition of the hepatic rat organic anion transporting polypeptides, Oatp1 and Oatp2. Hepatology. 2000 Jul;32 (1) :82-6.|[3]Rosette C, et al. Anti-inflammatory and immunomodulatory activities of rifamycin SV. Int J Antimicrob Agents. 2013 Aug;42 (2) :182-6. |[4]Tsukamura M, et al. Antituberculous Action of Rifamycin SV* In Vitro and In Vivo Studies. The Journal of Antibiotics, Series A, 1962, 15 (5) : 216-224.|[5]Saito K, et al. Rifamycin action on RNA polymerase in antibiotic-tolerant Mycobacterium tuberculosis results in differentially detectable populations. Proc Natl Acad Sci U S A. 2017 Jun 13;114 (24) :E4832-E4840.|[6]Jallouli M, et al. Rifamycin lavage in the treatment of experimental intra-abdominal infection. J Surg Res. 2009 Aug;155 (2) :191-4.|[7]Zhang M, et al. Treatment of tuberculosis with rifamycin-containing regimens in immune-deficient mice. Am J Respir Crit Care Med. 2011 May 1;183 (9) :1254-61.|[8]Omansen TF, et al. High-Dose Rifamycins Enable Shorter Oral Treatment in a Murine Model of Mycobacterium ulcerans Disease. Antimicrob Agents Chemother. 2019 Jan 29;63 (2) :e01478-18.|[9]Özbay C, et al. Ototoxic effect of topical rifamycin SV applied in the middle ear of rats. The Turkish Journal of Ear Nose and Throat, 2017, 27 (1) : 31-38.|[10]Okolicsanyi L, et al. Influence of rifamycin SV on bile acid metabolism in rats. Naunyn Schmiedebergs Arch Pharmacol. 1980 Aug;313 (2) :171-4.|[11]Dijkmans B A C, et al. Efficacy of rifamycin SV and vancomycin against Bacteroides fragilis in vitro and in experimentally infected mice. Current Microbiology, 1985, 12: 53-58.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Natural Products

Clinical Information

Launched

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Cradd (NM_009950) Mouse Tagged ORF Clone
MG202001 10 µg

Cradd (NM_009950) Mouse Tagged ORF Clone

Sign In for Pricing
View Details
Biotin Conjugated Rabbit Polyclonal Antibody to Feline IgG
BA-2356-2 2 mL

Biotin Conjugated Rabbit Polyclonal Antibody to Feline IgG

Sign In for Pricing
View Details
BssMI, 100U
RV1192 100 U

BssMI, 100U

Sign In for Pricing
View Details
APMAP Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI4E2]
TA504460BM 100 µL

APMAP Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI4E2]

Sign In for Pricing
View Details
Recombinant Human HRAS/GTPase Hras Protein (His Tag)
PKSH030919-01 100 µg

Recombinant Human HRAS/GTPase Hras Protein (His Tag)

Sign In for Pricing
View Details
Recombinant Human HRAS/GTPase Hras Protein (His Tag)
PKSH030919-02 1 mg

Recombinant Human HRAS/GTPase Hras Protein (His Tag)

Sign In for Pricing
View Details