JX06
JX06 is a potent, selective and covalent inhibitor of PDK. JX06 inhibits PDK1, PDK2 and PDK3 with IC50s of 49 nM, 101 nM, and 313 nM, respectively. JX06 inhibits PDK1 activity via covalently binding to a cysteine residue in an irreversible manner. JX06 shows significant antitumor activity[1].
Product Specifications
CAS Number
729-46-4
UNSPSC
12352005
Hazard Statement
H302, H315, H317, H319, H332, H373, H410
Target
Apoptosis; PDHK
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jx06.html
Purity
99.78
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
S=C(N1CCOCC1)SSC(N2CCOCC2)=S
Molecular Formula
C10H16N2O2S4
Molecular Weight
324.51
Precautions
H302, H315, H317, H319, H332, H373, H410
References & Citations
[1]Wenyi S, et, al. JX06 Selectively Inhibits Pyruvate Dehydrogenase Kinase PDK1 by a Covalent Cysteine Modification. Cancer Res. 2015 Nov 15; 75 (22) : 4923-36.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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