JX06

JX06 is a potent, selective and covalent inhibitor of PDK. JX06 inhibits PDK1, PDK2 and PDK3 with IC50s of 49 nM, 101 nM, and 313 nM, respectively. JX06 inhibits PDK1 activity via covalently binding to a cysteine residue in an irreversible manner. JX06 shows significant antitumor activity[1].

Product Specifications

CAS Number

[729-46-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H317, H319, H332, H373, H410

Target

Apoptosis; PDHK

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/jx06.html

Purity

99.78

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

S=C(N1CCOCC1)SSC(N2CCOCC2)=S

Molecular Formula

C10H16N2O2S4

Molecular Weight

324.51

Precautions

H302, H315, H317, H319, H332, H373, H410

References & Citations

[1]Wenyi S, et, al. JX06 Selectively Inhibits Pyruvate Dehydrogenase Kinase PDK1 by a Covalent Cysteine Modification. Cancer Res. 2015 Nov 15; 75 (22) : 4923-36.