HCH6-1
HCH6-1 is a potent and competitive dipeptide antagonist of Formyl peptide receptor 1 (FPR1) . HCH6-1 inhibits chemotaxis, superoxide anion generation, and elastase release in human neutrophils specifically activated by fMLF (an FPR1 agonist) . HCH6-1 has protective effects against acute lung injury (ALI) in vivo and can be used for the research of FPR1-involved inflammatory lung diseases[1].
Product Specifications
CAS Number
[1435265-06-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Formyl Peptide Receptor (FPR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hch6-1.html
Purity
99.16
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(N[C@H](C(N[C@@H](C(OC)=O)CC1=CC=CC=C1)=O)CC2=CNC3=C2C=CC=C3)C4=CC=CC=C4
Molecular Formula
C28H27N3O4
Molecular Weight
469.53
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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