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Nisin

Nisin is a bacteriocin produced by a group of Gram-positive bacteria that belongs to Lactococcus and Streptococcus species. Nisin has antibacterial and anti-inflammatory activity[1][2][3].

Product Specifications

CAS Number

1414-45-5

UNSPSC

12352209

Target

Antibiotic; Bacterial

Type

Peptides

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Nisin.html

Solubility

H2O : 6.67 mg/mL (ultrasonic)

Smiles

O=C1N2[C@@](CCC2)(C(=O)NCC(=O)N[C@H](C(N[C@H](C(N[C@@H]3[C@H](C)SC[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]4[C@H](C)SC[C@]5(C(=O)N[C@@H](CC6=CN=CN6)C(=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC7=CN=CN7)C(N[C@H](C(NC(C(N[C@@H](CCCCN)C(O)=O)=O)=C)=O)C(C)C)=O)=O)[C@H](CC)C)=O)CO)=O)CS[C@@H](C)[C@@](NC(=O)[C@H](C)NC4=O)(C(=O)N5)[H])[H])=O)CCCCN)=O)CCSC)=O)CC(N)=O)=O)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)CNC3=O)=O)CCCCN)=O)CS[C@@H](C)[C@H]1NC(=O)[C@H]8NC(=O)[C@H](CC(C)C)NC(=O)C(=C)NC(=O)[C@]([C@H](CC)C)(NC(=O)[C@H](NC(/C(/NC([C@H]([C@H](CC)C)N)=O)=C/C)=O)CSC8)[H])[H]

Molecular Formula

C143H230N42O37S7

Molecular Weight

3354.07

References & Citations

[1]Shin JM, et al. Biomedical applications of nisin. J Appl Microbiol. 2016 Jun;120 (6) :1449-65.|[2]de Carvalho Clímaco M, et al. Nisin Induces Cell-Cycle Arrest in Free-Living Amoebae Acanthamoeba castellanii. Acta Parasitol. 2022 Mar;67 (1) :511-517.|[3]Jia Z, et al. Nisin reduces uterine inflammation in rats by modulating concentrations of pro- and anti-inflammatory cytokines. Am J Reprod Immunol. 2019 May;81 (5) :e13096.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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