(3S,5R) -Fluvastatin (sodium)

(3S,5R) -Fluvastatin sodium ((3S,5R) -XU 62-320) is the (3S,5R) -enantiomer of Fluvastatin. Fluvastatin is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway[1].

Product Specifications

CAS Number

[94061-81-1]

Product Name Alternative

(3S,5R) -XU 62-320

UNSPSC

12352005

Target

HMG-CoA Reductase (HMGCR)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/3s-5r-fluvastatin-sodium.html

Purity

98.16

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

FC1=CC=C(C2=C(/C=C/[C@H](O)C[C@H](O)CC(O[Na])=O)N(C(C)C)C3=C2C=CC=C3)C=C1

Molecular Formula

C24H25FNNaO4

Molecular Weight

433.45

References & Citations

[1]Araújo FA, Rocha MA, Capettini LS, et al. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (fluvastatin) decreases inflammatory angiogenesis in mice. APMIS. 2012 24.