Phospho-Ask1 (Thr838) Rabbit APC Conjugate

<strong>Phospho-Ask1 (Thr838) Rabbit APC Conjugate </strong>_x000D_ <strong>Catalog number:</strong> B2018560_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 25 ug_x000D_ <strong>Molecular Weight or Concentration:</strong> N/A_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> 2-8°C_x000D_ <strong>Keywords:</strong> Apoptosis signal-regulating kinase 1, Mitogen-activated protein kinase kinase kinase 5, MAPK/ERK kinase kinase 5, MAP3K5, MAPKKK5, MEKK5_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Cho YC, Park JE, Park BC, Kim JH, Jeong DG, Park SG, Cho S. Cell cycle-dependent Cdc25C phosphatase determines cell survival by regulating apoptosis signal-regulating kinase 1 Cell Death Differ. 2015 Oct;22(10):1605-17._x000D_ 2: Patel P, Naik MU, Golla K, Shaik NF, Naik UP. Calcium-induced dissociation of CIB1 from ASK1 regulates agonist-induced activation of the p38 MAPK pathway in platelets Biochem J. 2019 Oct 15;476(19):2835-2850._x000D_ 3: Zhang Q, Wu X, Zhang H, Wu Q, Fu M, Hua L, Zhu X, Guo Y, Zhang L, You Q, Wang L. Protein Phosphatase 5-Recruiting Chimeras for Accelerating Apoptosis-Signal-Regulated Kinase 1 Dephosphorylation with Antiproliferative Activity J Am Chem Soc. 2023 Jan 18;145(2):1118-1128._x000D_ 4: Nadeau PJ, Charette SJ, Landry J. REDOX reaction at ASK1-Cys250 is essential for activation of JNK and induction of apoptosis Mol Biol Cell. 2009 Aug;20(16):3628-37._x000D_ 5: Bunkoczi G, Salah E, Filippakopoulos P, Fedorov O, Müller S, Sobott F, Parker SA, Zhang H, Min W, Turk BE, Knapp S. Structural and functional characterization of the human protein kinase ASK1 Structure. 2007 Oct;15(10):1215-26._x000D_ 6: Jung H, Seong HA, Ha H. Murine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr 838 phosphorylation J Biol Chem. 2008 Dec 12;283(50):34541-53._x000D_ 7: Harrison SA, Wong VW, Okanoue T, Bzowej N, Vuppalanchi R, Younes Z, Kohli A, Sarin S, Caldwell SH, Alkhouri N, Shiffman ML, Camargo M, Li G, Kersey K, Jia C, Zhu Y, Djedjos CS, Subramanian GM, Myers RP, Gunn N, Sheikh A, Anstee QM, Romero-Gomez M, Trauner M, Goodman Z, Lawitz EJ, Younossi Z; STELLAR-3; STELLAR-4 Investigators. Selonsertib for patients with bridging fibrosis or compensated cirrhosis due to NASH: Results from randomized phase III STELLAR trials J Hepatol. 2020 Jul;73(1):26-39._x000D_ 8: Li DJ, Tong J, Li YH, Meng HB, Ji QX, Zhang GY, Zhu JH, Zhang WJ, Zeng FY, Huang G, Hua X, Shen FM, Wang P. Melatonin safeguards against fatty liver by antagonizing TRAFs-mediated ASK1 deubiquitination and stabilization in a β-arrestin-1 dependent manner J Pineal Res. 2019 Nov;67(4):e12611._x000D_ 9: Song J, Cho KJ, Cheon SY, Kim SH, Park KA, Lee WT, Lee JE. Apoptosis signal-regulating kinase 1 (ASK1) is linked to neural stem cell differentiation after ischemic brain injury Exp Mol Med. 2013 Dec 20;45(12):e69._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/11689443">10: Morita K, Saitoh M, Tobiume K, Matsuura H, Enomoto S, Nishitoh H, Ichijo H. Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress EMBO J. 2001 Nov 1;20(21):6028-36. </a>_x000D_ _x000D_ <strong>Products Related to Phospho-Ask1 (Thr838) Rabbit APC Conjugate can be found at</strong> <a href="https://moleculardepot.com/product-category/Conjugates/"> Conjugates</a>