Cyclo (RGDyK) (trifluoroacetate)
Cyclo (RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.
Product Specifications
CAS Number
250612-42-1
UNSPSC
12352209
Hazard Statement
H302, H372, H410
Target
Integrin
Type
Peptides
Related Pathways
Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Cyclo_RGDyK__trifluoroacetate.html
Purity
99.92
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(N[C@H](C(N[C@H]1CCCNC(N)=N)=O)CCCCN)[C@H](NC([C@@H](NC(CNC1=O)=O)CC(O)=O)=O)CC2=CC=C(O)C=C2.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
Molecular Formula
C31H43F6N9O12
Molecular Weight
847.72
Precautions
H302, H372, H410
References & Citations
[1]Haubner R, et al. Glycosylated RGD-containing peptides: tracer for tumor targeting and angiogenesis imaging with improved biokinetics. J Nucl Med. 2001 Feb;42 (2) :326-36.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
αvβ3
Citation 01
Pharmaceuticals (Basel) . 2021 Mar 14;14 (3) :260.|Stem Cell Res Ther. 2022 Jul 18;13 (1) :327.|Biochem Pharmacol. 2023 Nov:217:115808.|J Adv Res. 2025 May 25:S2090-1232 (25) 00370-4.
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