Cyclo (RGDyK) (trifluoroacetate)

Cyclo (RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.

Product Specifications

CAS Number

[250612-42-1]

UNSPSC

12352209

Hazard Statement

H302, H372, H410

Target

Integrin

Type

Peptides

Related Pathways

Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Cyclo_RGDyK__trifluoroacetate.html

Purity

99.92

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(N[C@H](C(N[C@H]1CCCNC(N)=N)=O)CCCCN)[C@H](NC([C@@H](NC(CNC1=O)=O)CC(O)=O)=O)CC2=CC=C(O)C=C2.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F

Molecular Formula

C31H43F6N9O12

Molecular Weight

847.72

Precautions

H302, H372, H410

References & Citations

[1]Haubner R, et al. Glycosylated RGD-containing peptides: tracer for tumor targeting and angiogenesis imaging with improved biokinetics. J Nucl Med. 2001 Feb;42 (2) :326-36.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

No Development Reported

Isoform

αvβ3

Citation 01

Pharmaceuticals (Basel) . 2021 Mar 14;14 (3) :260.|Stem Cell Res Ther. 2022 Jul 18;13 (1) :327.|Biochem Pharmacol. 2023 Nov:217:115808.|J Adv Res. 2025 May 25:S2090-1232 (25) 00370-4.