SGK1-IN-2

SGK1-IN-2 (14h) is a selective SGK1 (serum and glucocorticoid regulated kinase 1) inhibitor, with an IC50 of 5 nM at 10 μM ATP concentration[1].

Product Specifications

CAS Number

[1426214-64-3]

UNSPSC

12352005

Target

SGK

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sgk1-in-2.html

Purity

98.36

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

O=S(C1=CC(Cl)=CC=C1Cl)(NC2=CC=C(C3=CN=C4C(NN=C4N)=N3)C=C2)=O

Molecular Formula

C17H12Cl2N6O2S

Molecular Weight

435.29

References & Citations

[1]Halland N, et al. Discovery of N-[4- (1H-Pyrazolo[3,4-b]pyrazin-6-yl) -phenyl]-sulfonamides as Highly Active and Selective SGK1 Inhibitors. ACS Med Chem Lett. 2014 Oct 23;6 (1) :73-8.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

SGK1

Available Sizes

Curated Selection

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