SGK1-IN-2
SGK1-IN-2 (14h) is a selective SGK1 (serum and glucocorticoid regulated kinase 1) inhibitor, with an IC50 of 5 nM at 10 μM ATP concentration[1].
Product Specifications
CAS Number
[1426214-64-3]
UNSPSC
12352005
Target
SGK
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sgk1-in-2.html
Purity
98.36
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
O=S(C1=CC(Cl)=CC=C1Cl)(NC2=CC=C(C3=CN=C4C(NN=C4N)=N3)C=C2)=O
Molecular Formula
C17H12Cl2N6O2S
Molecular Weight
435.29
References & Citations
[1]Halland N, et al. Discovery of N-[4- (1H-Pyrazolo[3,4-b]pyrazin-6-yl) -phenyl]-sulfonamides as Highly Active and Selective SGK1 Inhibitors. ACS Med Chem Lett. 2014 Oct 23;6 (1) :73-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SGK1
Available Sizes
Curated Selection
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