AT-533
AT-533 is a potent Hsp90 and HSV inhibitor. AT-533 suppresses tumor growth and angiogenesis by blocking the HIF-1α/VEGF/VEGFR-2 signaling pathway. AT-533 also inhibits the activation of the downstream pathways, including Akt/mTOR/p70S6K, Erk1/2 and FAK. AT-533 inhibits the tube formation, cell migration, and invasion of human umbilical vein endothelial cells (HUVECs) [1][2][3].
Product Specifications
CAS Number
908112-37-8
UNSPSC
12352005
Target
Akt; ERK; FAK; HIF/HIF Prolyl-Hydroxylase; HSP; HSV; NF-κB; VEGFR
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/at-533.html
Purity
98.38
Solubility
DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC1=NN(C2=CC(N[C@@H]3CC[C@H](CC3)O)=C(C=C2)C(N)=O)C(CC(C)(C4)C)=C1C4=O
Molecular Formula
C23H30N4O3
Molecular Weight
410.51
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Akt; ERK1; ERK2; HSP90; HSV-1; NF-κB
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Gm14477 CRISPRa sgRNA lentivector (set of three targets)(Mouse)
AKAP7 Antibody - middle region : HRP (ARP36691_P050-HRP)
Anti-GTF2F2 Antibody Picoband® Fluoro550 Conjugated
![Rabbit Polyclonal VGLL3 Antibody [HRP]](https://cdn.genprice.uk/genprice/uk/genprice4.webp)