MK-0812

MK-0812 is a potent and selective CCR2 antagonist with low nM affinity for CCR2.

Product Specifications

CAS Number

[624733-88-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

CCR

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/mk-0812.html

Purity

99.89

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@]1(C(C)C)C[C@H](N[C@H]2CCOC[C@H]2OC)CC1)N3CCC(N=CC(C(F)(F)F)=C4)=C4C3

Molecular Formula

C24H34F3N3O3

Molecular Weight

469.54

Precautions

H302, H315, H319

References & Citations

[1]Wisniewski T, et al. Assessment of chemokine receptor function on monocytes in whole blood: In vitro and ex vivo evaluations of a CCR2 antagonist.J Immunol Methods. 2010 Jan 31;352 (1-2) :101-10.|[2]Min SH, et al. Pharmacological targeting reveals distinct roles for CXCR2/CXCR1 and CCR2 in a mouse model of arthritis.Biochem Biophys Res Commun. 2010 Jan 1;391 (1) :1080-6.