Ebselen derivative 1
Product Specifications
UNSPSC Description
Ebselen derivative 1 (Compound 19) is a glutathione peroxidase (GPx) mimic with oral activity. Ebselen derivative 1 demonstrates significant protective effects against cisplatin (HY-17394)-induced hair cell (HC) damage both in vitro and in vivo, effectively reducing oxidative stress, apoptosis, and ferroptosis in hair cells. Ebselen derivative 1 can be utilized in the research of cisplatin (HY-17394)-induced hearing loss [1].
Target Antigen
Apoptosis; Ferroptosis
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ebselen-derivative-1.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=C([Se]N1C3=CC=CN=C3)C(OC)=CC=C2
Molecular Weight
305.19
References & Citations
[1]Wang W, et al. Quantum chemistry calculation-aided discovery of potent small-molecule mimics of glutathione peroxidases for the treatment of cisplatin-induced hearing loss. Eur J Med Chem. 2024;271:116404.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-163506/Ebselen-derivative-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-163506/
Clinical Information
No Development Reported
CAS Number
3030492-59-9
Curated Selection
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