Ginkgolide B
Ginkgolide B (BN-52021), a terpene lactone, is a potent platelet activating factor antagonist. Ginkgolide B protects endothelial cells via the activation of PXR from injuries induced by xeno- and endobiotics. Ginkgolide B can pass through the brain-blood barrier. Ginkgolide B has anti-oxidant, anti-inflammatory, anti-tumor, and anti-apoptotic activity. Ginkgolide B has marked neuroprotective effects against ischemia-induced impairments[1][2].
Product Specifications
CAS Number
15291-77-7
Product Name Alternative
BN-52021
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Apoptosis; Platelet-activating Factor Receptor (PAFR) ; Pregnane X Receptor (PXR)
Type
Natural Products
Related Pathways
Apoptosis; GPCR/G Protein; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Ginkgolide-B.html
Concentration
10mM
Purity
99.96
Solubility
DMSO : 100 mg/mL
Smiles
O[C@@H]1C(C2([C@H]3O)[C@](OC3=O)([H])O4)([C@@](O5)([H])C[C@H]2C(C)(C)C)C4(C5=O)[C@@](O)([C@@H]6C)[C@@]1([H])OC6=O
Molecular Formula
C20H24O10
Molecular Weight
424.40
Precautions
H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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